The next challenges in neutrino and direct Dark Matter (DM) searches will require increasingly massive detectors, and increasingly complex, to cover a wide range of scientific goals. The involved energy range extends from a few tens of eV induced by low mass WIMPs and neutrinos via coherent scattering, to solar neutrinos and neutrinoless double beta decay (~MeV scale), Supernova neutrinos (~10 MeV), and accelerator neutrinos (~GeV). Experiments specifically designed for DM searches have the potential to explore the energy range up to Supernova neutrinos.