In this talk I will review the physics of Euclidean wormholes in a holographic context. By studying the properties of various observables on these Euclidean backgrounds holographically, we found the common behaviour that there are interactions between the quantum field theories that live on each of the wormholes' boundaries. These interactions are very weak in the UV and become strong in the IR. Based on these results we proposed a holographic dual in terms of a tripartite system where the two boundary field theories are connected through a non-holographic topological messenger theory in one higher dimension. We explicitly constructed such a system in terms of two matrix quantum mechanics models coupled through a two dimensional Yang-Mills theory. This proposal is in agreement with the usual holographic dictionary. I will also comment on the possible use of such tripartite models for the description of cosmological spacetimes.